Molecular Regulation of Adult Neurogenesis in Anxiety and Depression

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Molecular Regulation of Adult Neurogenesis in Anxiety and Depression

Experienced Researcher 1. This position has been filled

Supervisor:   Eleanor Coffey. Host institution:   Turku Centre for Biotechnology, Åbo Akademi University

Duration:  24 months.

Description:Stress kinase regulation of adult neurogenesis

This project is part of a consortium effort to study the mechanism whereby stress kinases regulate adult neurogenesis and to develop monitoring tools to image adult neurogenesis in situ in brain. We are looking for experienced candidates with demonstrated prior experience in several of the following areas: brain anatomy and histological staining, advanced fluorescence imaging, animal surgery, advanced stereology, Neurolucida tracing, proteomics, bioinformatics. Several people will be recruited to this project and the final definition of tasks for this postdoctoral researcher will be negotiated depending on previous experience of the researcher and their future goals in terms of research training.

The Coffey lab studies stress kinase function in brain with a recent focus on the regulation of neurogenesis in adult brain and the accompanying processes i.e. neuronal migration, dendrite elaboration and synaptic integration. The goals of the project are to (i) develop novel monitoring tools with which to image neurogenesis in patients, this involves a proteomics study that is in close collaboration with the lab of Peter James at Lund University in Sweden, and to (ii) define the molecular mechanisms whereby stress kinases regulate anxiety and depressive responses, this utilizes transgenic mice lacking stress kinase pathway genes, to study glucocorticoid function and NMDA responses in the context of depressive disorders. Methods employed can include live confocal and multiphon imaging, STED imaging of dendritic spines, molecular cloning, dendrite and spine architecture analysis, animal behavior, in utero electroporation, brain phosphor and membrane proteomics and bioinformatics.

Candidates should have up to but not more than 5 years research experience since completion of the MSc degree in the field of neuroscience or closely related discipline. A PhD degree is preferred. The successful recruit will be trained in the above methods according to the research line and will be required to take on supervisory responsibilities and manuscript writing. It is expected that successful candidate will produce two-peer reviewed articles during this time.The post includes secondments in collaborating labs of the consortium.

Early Stage Researcher 1. This position has been filled.

Supervisor:   Eleanor Coffey. Host institution:   Turku Centre for Biotechnology, Åbo Akademi University, Turku, Finland. Duration:  36 months.

Early Stage Researcher 2. This position has been filled.

Supervisor:   Eleanor Coffey. Host institutionTurku Centre for Biotechnology, Åbo Akademi University

Duration:  36 months.
Description: Protein kinase regulation of structural changes in brain associated with depression